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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: The purpose of this study was to investigate the expression of pituitary tumor transforming gene (PTTGWe detected PTTG protein and bFGF in OSCC tissues from 56 cases using the streptavidin-biotin peroxidaseThe results were as follows: (1) Positive rates of PTTG protein and bFGF were 78.2% and 67.3% in OSCCPTTG protein expression was positively correlated with bFGF ( = 0.382, <0.05); (2) PTTG protein emittedPTTG protein expression conforms to bFGF in OSCC tissues and Tca8113 cells.

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodesthe candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: This gene, hereby named LY6A, reversely overlaps with a lncRNA gene in the majority of exonicWe found that LY6A is aberrantly expressed in pituitary tumors, but not in normal pituitary tissuesWe cloned the full-length LY6A cDNA, whose encoded protein sequence, domain architecture, andEctopic expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Scamodel gene for studying gene regulatory and evolutionary mechanisms.

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymousSNP     GPI-anchored protein    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: Hepatitis B virus X protein (HBx), a 17-kd protein encoded by X gene of hepatitis B virus (HBV), hasThe aim of the study is to investigate the extracellular regulated protein kinases (ERKs) pathway ofHBx on glomerular mesangial cell (GMC) proliferation and tumor necrosis factor-α (TNF-α) expressionThe HBV X gene was amplified by polymerase chain reaction (PCR), inserted into the eukaryotic expressionPCI-neo containing HBV X gene (pCI-neo-X) was then transfected into cultured GMC line via liposome.

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 49-56 doi: 10.1007/s11684-009-0012-y

Abstract: The aim of this paper was to study the differential gene expression of giant cell tumor of bone (GCTB) by gene chip technology.The gene expression disparity between the GCTB samples and normal bony callus was significantly differentspecimens, with 25 genes up-regulated and 22 down-regulated including the extracellular matrix and transforming-relatedSpecific gene spectrum associated with GCTB can be identified by cDNA microarray, which will be the foundation

Keywords： giant cell tumor of bone     gene     microarray     cDNA    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivityof tumor cells

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: In this study, survival fraction at 2Gy (SF2) values of eight human tumor cell lines (including fourWe found that the expression of same protein in different cell lines and the expression of three proteinsThe SF2 values were also different in eight tumor cell lines and there was a positive correlativity betweenThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predictingthe radiosensitivity of tumor cells.

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 283-285 doi: 10.1007/s11684-008-0053-7

Abstract: The aim of this paper is to report a new coding variance of the gene, a candidate for autoimmune diseases

Keywords： D-HPLC mutation     development     autoimmune     PCR-RFLP     candidate    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: To determine whether squamous cell carcinoma antigen recognized by human T cell 3 (SART3) gene can induceantitumor immunity against tumor cells which express the gene, we constructed mouse tumor cells expressingAfter subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAfter vaccination, tumor occurrence and tumor growth speed was reduced.The vaccine also shows activity in tumor treatment.

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 639-645 doi: 10.1007/s11684-019-0701-0

Abstract: Esophageal cancer-related gene-4 ( ) is cloned from the normal epithelium of the esophagus.during tumorigenesis, and expression levels are inversely correlated with the malignant phenotype of tumorcells, validating that is a real tumor suppressor gene.Unlike other tumor suppressor genes that usually encode membrane or intracellular proteins, encodessuch as promoting/suppressing inflammation, inducing neuron senescence, stimulating the hypothalamus–pituitary–adrenal

Keywords： tumor suppressor gene     esophageal cancer-related gene-4     cardiovascular disease     hypoxia    

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Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 101-111 doi: 10.1007/s11684-019-0698-4

Abstract: To isolate the potential somatic hypermutational tumor from microsatellite instability low/microsatellite

Keywords： mismatch repair protein deficiency (MMR-D)     microsatellite instability (MSI)     short tandem repeats (STR)     gastrointestinal tumor     hypermutability    

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Atypical pituitary hormone–target tissue axis

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 1-17 doi: 10.1007/s11684-022-0973-7

Abstract: A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glandsHowever, a number of studies have shown that multiple types of pituitary hormone receptors are widelyEach pituitary gland-derived hormone exhibits a wide range of nonconventional biological effects in thesewhen they act on non-classical organs were summarized, defined by the novel concept of an “atypical pituitaryThe continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could

Keywords： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic hormone     prolactin    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract: In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Esophageal cancer-related gene-4 ( ), which is initially known as a new candidate tumor suppressor geneECRG4 is unique in its cytokine-like functional pattern and epigenetically-regulated gene expressionThe gene can be released from the cell membrane upon activation and detected in liquid biopsy, thus offering

Keywords： ECRG4     tumor suppressor gene     sentinel molecule     precision medicine     cell senescence     epithelium homeostasis    

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TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with TNF-alpha-308 gene

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 220-224 doi: 10.1007/s11684-010-0025-6

Abstract: This study examined the inhibitory effect of triptolid (TP) on tumor necrosis factor-α (TNF-αperipheral blood monocular cells (PBMCs) and the association of the inhibitory effect with TNF-α-308 geneGene polymorphism at A-G site 308 in the promoter region of TNF-α gene was detected in 42 It was concluded that gene polymorphism at TNF-α-308 sites may relate to the secretion of TNF-α

Keywords： arthritis     rheumatoid     molonuclear cells     tumor necrosis factor     gene polymorphisms     triptolid    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell linestranscription activity was determined by dual-luciferase report assay, and enhanced green fluorescent proteindual-luciferase reporter assay showed that the promoter transcription activity in digestive system tumorExpression of green fluorescent protein (GFP) under the control of XAF1 promoter in the three digestive

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 379-383 doi: 10.1007/s11684-009-0073-y

Abstract: p38 regulated/activated protein kinase (PRAK) plays a key role in cell senescence and tumor suppressionTaken together, gene knockout in MEF cells leads to cell cycle arrest and proliferation inhibition.

Keywords： p38 regulated/activated protein kinase     gene knockout     cell cycle     cell proliferation    

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Title Author Date Type Operation

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodesthe candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Gene expression disparity in giant cell tumor of bone

Xiaohua PAN, Shuhua YANG, Deming XIAO, Yong DAI, Lili REN

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivityof tumor cells

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)

QU Yanchun, YANG Ze, SUN Liang, JI Linong

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

Rui Zhou, Yuanshu Liu, Wenjun Huang, Xitong Dang

Journal Article

Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit

Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li

Journal Article

Atypical pituitary hormone–target tissue axis

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Journal Article

TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with TNF-alpha-308 gene

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

Journal Article